Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population. Epub 2015 Mar 31.ĭomínguez-Cruz MG, Muñoz ML, Totomoch-Serra A, García-Escalante MG, Burgueño J, Valadez-González N, et al. Diabetes susceptibility in Mayas: evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes. Lara-Riegos JC, Ortiz-López MG, Peña-Espinoza BI, Montúfar-Robles I, Peña-Rico MA, Sánchez-pozos K, et al. The diabesity epidemic in the light of evolution: insights from the capacity-load model. Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications. ![]() Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging. Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos. doi: 10.1007/s1188-y.Ĭid-Soto MA, Martínez-Hernández A, García-Ortíz H, Córdova EJ, Barajas-Olmos F, Centeno-Cruz F, et al. Epidemiology of Diabetes Mellitus and Cardiovascular Disease. For this purpose, we resort to primary sources of information, including original research articles and chapters from edited books about diabesity and socio-historical essays on the Maya population. Finally, we propose that the failure of insulin secretion and glucolipotoxicity are common factors and a possible unifying factor of diabesity among the Maya. ![]() In this descriptive review, we first describe the phenotypic and genotypic traits associated with diabesity we then discuss the role of the sociocultural factors that have impacted the dietary pattern of the Maya and the available evidence regarding the phenotypic characteristics acquired during the early stages of development and their possible repercussions on metabolism and the presence of obesity and diabetes. In this article, we aim to analyze the phenomenon of diabesity in the context of the Yucatecan Maya population, given the demographic importance of this ethnic group in the country and due to the high prevalence of diabetes and obesity. Taking the Maya from Yucatan as a case study, we propose that an ecological perspective of diabesity allows for the identification of the presence of factors at different scales of analysis that help to understand the phenomenon. Diabesity is particularly relevant in the native population of Mexico. The high coexistence and complex interaction between these pathologies have generated an initial characterization of the phenomenon called diabesity, however, it is necessary to resort to comprehensive theoretical frameworks that contribute to the understanding of this phenomenon. ![]() Diabetes and obesity are diseases of relevance in the epidemiological context of Yucatan.
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